Advantages of Vardenafil
Vardenafil (Ledra) is a potent, highly selective form of Viagra that is about 10 times as effective as sildenafil. The drug can significantly enhance the erectile function of the penis, and the effect is rapid, the patient can get a full erection as early as 10 minutes after oral administration and then have sex with a loved one. So far, it is the fastest-acting Viagra, and it takes only a shower. Studies have shown that vardenafil (Ledra) is a safe and effective oral medication for the treatment of ED.
- 1. Vardenafil is 10 times more effective than sildenafil.
- 2. So far, the fastest-acting Viagra, the fastest 10 minutes to get a full erection.
- 3. Significantly enhance the hardness and thickness after erection.
It’s pure science time:
Since sildenafil (Xiaolan Tablet) began to treat erectile dysfunction (ED) in 1998, the development and research of this type of drug have continued to deepen, in order to find drugs with higher selectivity, stronger efficacy, and fewer adverse reactions, Provide safer and more effective treatment for different types of ED patients. As an upgraded version of sildenafil, vardenafil (Aleida) is more effective and has fewer side effects. It was developed by Bayer, a company with the same name as Pfizer.
Mechanism of action: During sexual stimulation, the corpus cavernosum releases nitric oxide (NO), resulting in the formation of cyclic guanosine monophosphate (cGMP). Please remember that NO and cGMP are very important in penile erection, as long as their concentrations are increased, the erection will be good. A series of biochemical reactions are subsequently triggered, with increased blood flow to the penis and swelling of the cavernous tissue, resulting in an erection of the penis.
The effect of vardenafil (Alida) is to increase the content of cGMP, indirectly increase the effect of endogenous NO, and make the little brother erect, but only under the condition of sexual stimulation. Let Mengmeng stand up and whistle first.
Features of Vardenafil
1. Vardenafil is highly selective for PDE5
Vardenafil must act on an enzyme to increase cGMP concentration, and this enzyme is PDE5. We don’t have to worry about what this enzyme is, just remember that it is more distributed in the penis. Vardenafil likes to act on this enzyme. It is precisely because of this high selectivity that vardenafil not only has a significant effect but also greatly reduces the incidence of adverse reactions.
2. Vardenafil has a potent inhibitory effect on PDE5
Inhibiting the activity of PDE5 can increase the concentration of cGMP and make the penis erect. Vardenafil can specifically inhibit PDE5, the effect is about 10 times that of sildenafil (Viagra) [1], and 13 times that of tadalafil (Cialis). That is, vardenafil is by far the most potent PDE5 inhibitor.
3. Vardenafil significantly improves the hardness and thickness of penile erections in ED patients
Two randomized, double-blind, placebo-controlled crossover studies have shown that a single oral dose of vardenafil (Aleida) 10-40 mg can significantly improve the hardness and thickness of penile erections in patients with mild to moderate ED and Significantly prolongs the maintenance time of penile erection.
4. Vardenafil works quickly
A full erection can be achieved as early as 10 minutes after taking vardenafil. Vardenafil (Ledra) is the fastest-acting PDE5 inhibitor to date.
The onset time of vardenafil (Ledra) in the treatment of erectile dysfunction (ON TIME) was a randomized, double-blind, parallel-group trial in 665 male patients with ED who received oral vardenafil 10 mg or 20 mg or Sexual activity started immediately after placebo. The efficacy of the vardenafil 20 mg group and 10 mg group was significantly higher than that of the placebo group at each time point > 11 min and > 10 min, respectively (P < 0.025).
5. Safe to take every day
Pharmacokinetic studies have shown that the drug can be metabolized in a large amount, and continuous daily administration will not produce long-term drug accumulation.
This feature differs from tadalafil, which has a longer elimination half-life and is discouraged from daily use as the long-term safety of continuous daily dosing has not been proven.
6. Vardenafil is rapidly absorbed and is not affected by food
Vardenafil (Aleida) is rapidly absorbed after oral administration, and some men can reach maximum plasma concentrations within 15 minutes after taking the drug.
There was no difference in the rate or extent of absorption of vardenafil between the moderate-fat diet and the fasted state. Can be taken with food.